I don't know what is RUN state of drive. Never seen this.
Coming to your issue, if few read error and disk going on good state then you may no need to replace the drive.
Still if you want to replace any drive which is part of any vdisk then you can simply pull out the drive and replace it. You no need to worry about data write or data corruption - all will be taking care by MSA Controller and RAID level of the vdisk.
Hope this helps!
Regards
Subhajit
I am an HPE employee
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