Many Thanks for all your replies. Has put my mind at rest for this work.
On the last question. Just a bit concerend as I am currently testing with the 2 MSAs replicating on local area network with only 4 * 1Tb volumes & rate of change is not much. When this goes into production the 2 MSAs will be replicating over a WAN & will have 4 * 4Tb LUNs.
The worklad will be 12 VMs as hosts will be vmware vSphere.