Your issue seems to be related to VMWare specific.
You can browse your datastore and try to check apart from Virtual Machine VMDK files what all files there which is consuming all space. It could be some big files for some reason there. You need to involve VMWare expert to troubleshoot this.
You can also search in Google with "insufficient disk space" error message and you will get lots of help from VMWare,
You should also check from VMWare console or CLI that if new datastore getting locked for some reason. Please find the below article to get some idea,
https://www.petenetlive.com/KB/Article/0001292
From MSA perspective, I would suggest to upgrade Controller firmware to latest version TS252P005,
www.hpe.com/storage/MSAFirmware
Request you not to keep the forum open for long time if don't get any help as here everyone will be MSA expert only.
Hope this helps!
Regards
Subhajit
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